The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2013
Filed:
Aug. 07, 2008
Yuqiang Wang, Guangzhou, CN;
Xiaojian Jiang, Guangzhou, CN;
Jie Jiang, Guangzhou, CN;
Zaijun Zhang, Guangzhou, CN;
Zhaoqi Yang, Guangzhou, CN;
Pei Yu, Guangzhou, CN;
Yuqiang Wang, Guangzhou, CN;
Xiaojian Jiang, Guangzhou, CN;
Jie Jiang, Guangzhou, CN;
Zaijun Zhang, Guangzhou, CN;
Zhaoqi Yang, Guangzhou, CN;
Pei Yu, Guangzhou, CN;
Panorama Research Inc., Sunnyvale, CA (US);
Abstract
The present invention relates to an andrographolide derivative of the formula (I), wherein R, Rand Rare same or different substituents selected from hydrogen, substituted or unsubstituted organic acid radicals, inorganic acid radicals, alkyl, aryl or heteroaryl, and at least one of R, Rand Ris R-lipoic acid, S-lipoic acid or a mixture thereof, or corresponding dihydrolipoic acids thereof, or N-acetylcysteine radical. The derivative has good antitumor effect, can induce apoptosis of tumor cells, can directly kill Gram-positive bacteria () and drug resistance bacteria (MRSA5676 and MRSA5677), can inhibit the QS-system of Gram-negative bacteria (), can inhibit and destroy the formation of biofilm of; and exhibits significant hypoglycemic effect, so that it can be used in manufacture of medicaments for treatment of cancers, inflammation, diabetes, and bacterial and viral infections.