The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2013
Filed:
Sep. 25, 2008
Kenichi Onda, Tokyo, JP;
Kenichiro Imamura, Tokyo, JP;
Fumie Sato, Tokyo, JP;
Hiroyuki Moritomo, Tokyo, JP;
Yasuharu Urano, Tokyo, JP;
Yuki Sawada, Tokyo, JP;
Naoki Ishibashi, Tokyo, JP;
Keita Nakanishi, Tokyo, JP;
Kazuhiro Yokoyama, Tokyo, JP;
Shigetada Furukawa, Tokyo, JP;
Kazuhiro Momose, Tokyo, JP;
Kenichi Onda, Tokyo, JP;
Kenichiro Imamura, Tokyo, JP;
Fumie Sato, Tokyo, JP;
Hiroyuki Moritomo, Tokyo, JP;
Yasuharu Urano, Tokyo, JP;
Yuki Sawada, Tokyo, JP;
Naoki Ishibashi, Tokyo, JP;
Keita Nakanishi, Tokyo, JP;
Kazuhiro Yokoyama, Tokyo, JP;
Shigetada Furukawa, Tokyo, JP;
Kazuhiro Momose, Tokyo, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like.