The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2013
Filed:
Sep. 14, 2007
Lutz Weber, Germering, DE;
Vladimir Khazak, Brooklyn, NY (US);
Gunther Ross, Munich, DE;
Cedric Kalinski, Munich, DE;
Christoph Burdack, Munich, DE;
Lutz Weber, Germering, DE;
Vladimir Khazak, Brooklyn, NY (US);
Gunther Ross, Munich, DE;
Cedric Kalinski, Munich, DE;
Christoph Burdack, Munich, DE;
NexusPharma, Inc., Langhorne, PA (US);
Abstract
The present invention provides a compound selected from compounds of formula (A) as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (A) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (A) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.