The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2013
Filed:
Feb. 07, 2008
Applicants:
Thomas N. Wight, Seattle, WA (US);
Mervyn Merrilees, Auckland, NZ;
Inventors:
Thomas N. Wight, Seattle, WA (US);
Mervyn Merrilees, Auckland, NZ;
Assignee:
Benaroya Research Institute at Virginia Mason, Seattle, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/16 (2006.01); A61K 38/00 (2006.01); C12N 5/00 (2006.01); C12N 5/02 (2006.01); A61P 43/00 (2006.01); A61P 19/00 (2006.01); A61P 17/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Compositions and methods are provided for promoting elastin fiber formation (elastogenesis) in a cell, including methods that comprise contacting a cell that is capable of elastogenesis with (i) a mutated biglycan polypeptide that lacks chondroitin sulphate proteoglycan chains, (ii) a versican V3 isoform polypeptide that lacks most or all of the polypeptide regions encoded by one or more of exons 4, 5 or 6 or by exons 9-10 or 11-13, and/or with (iii) metastatin.