The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2013
Filed:
Jun. 21, 2004
Milica Radisic, Cambridge, MA (US);
Hyoungshin Park, Somerville, MA (US);
Robert Langer, Newton, MA (US);
Lisa Freed, Lexington, MA (US);
Gordana Vunjak-novakovic, Belmont, MA (US);
Milica Radisic, Cambridge, MA (US);
Hyoungshin Park, Somerville, MA (US);
Robert Langer, Newton, MA (US);
Lisa Freed, Lexington, MA (US);
Gordana Vunjak-Novakovic, Belmont, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The present invention provides new methods for the in vitro preparation of bioartificial tissue equivalents and their enhanced integration after implantation in vivo. These methods include submitting a tissue construct to a biomimetic electrical stimulation during cultivation in vitro to improve its structural and functional properties, and/or in vivo, after implantation of the construct, to enhance its integration with host tissue and increase cell survival and functionality. The inventive methods are particularly useful for the production of bioartificial equivalents and/or the repair and replacement of native tissues that contain electrically excitable cells and are subject to electrical stimulation in vivo, such as, for example, cardiac muscle tissue, striated skeletal muscle tissue, smooth muscle tissue, bone, vasculature, and nerve tissue.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile