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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8367383 B1

PDFFull Text
Date of Patent:
Feb. 05, 2013

Filed:

Aug. 14, 2012

Mutant Δ-5 desaturases mutated in the heme-binding motif (hpgg) and their use in making polyunsaturated fatty acids

Applicants:

Quinn Qun Zhu, West Chester, PA (US);

Dana M. Walters Pollak, Media, PA (US);

Inventors:

Quinn Qun Zhu, West Chester, PA (US);

Dana M. Walters Pollak, Media, PA (US);

Assignee:

E I du Pont de Nemours and Company, Wilmington, DE (US);

Attorney:
Primary Examiner:

David J Steadman

Int. Cl.
CPC ...
C12P 7/64 (2006.01); C12N 1/20 (2006.01); C12N 1/00 (2006.01); C12N 1/12 (2006.01); C12N 15/00 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to mutant Δ5 desaturases, which have the ability to convert dihomo-γ-linolenic acid [DGLA; 20:3 ω-6] to arachidonic acid [ARA; 20:4 ω-6] and/or eicosatetraenoic acid [ETA; 20:4 ω-3] to eicosapentaenoic acid [EPA; 20:5 ω-3] and which possess at least one mutation within the HPGG motif of the cytochome b-like domain. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturases, along with a method of making long chain polyunsaturated fatty acids ['PUFAs'] using these mutant Δ5 desaturases in oleaginous yeast, are disclosed.

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