The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2013
Filed:
Jul. 21, 2008
Anja Smith, Thornton, CO (US);
Scott Baskerville, Louisville, CO (US);
Devin Leake, Denver, CO (US);
Annaleen Vermeulen, Lafayette, CO (US);
Barbara Robertson, Boulder, CO (US);
Anastasia Khvorova, Boulder, CO (US);
Anja Smith, Thornton, CO (US);
Scott Baskerville, Louisville, CO (US);
Devin Leake, Denver, CO (US);
Annaleen Vermeulen, Lafayette, CO (US);
Barbara Robertson, Boulder, CO (US);
Anastasia Khvorova, Boulder, CO (US);
Dharmacon, Inc., Lafayette, CO (US);
Abstract
The disclosure provides methods for inhibiting the activity of a miRNA cluster in a cell, and also for screening a cell for a phenotype(s) of interest resulting from inhibition of a miRNA cluster. The methods use a cluster pool which comprises at least one miRNA inhibitor specific for each miRNA in the miRNA cluster. MiRNA inhibitors are described that induce apoptosis in breast cancer cells and hence are useful in the treatment of breast cancer. The disclosure also provides pharmaceutical compositions which are useful for the treatment of breast cancer; methods for inducing the nuclear translocation of NF-κB in a breast cancer cell; methods for inducing the nuclear translocation of c-Jun in a breast cancer cell; method for inhibiting the nuclear translocation of NF-κB in a breast cancer cell; and methods for providing prognostic medical information relating to breast cancer progression.