The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2013
Filed:
Jan. 04, 2007
Manne Satyanarayana Reddy, Hyderabad, IN;
Muppa Kishore Kumar, Hyderabad, IN;
Srinivasan Thirumalai Rajan, Hyderabad, IN;
Durgadas Shyla Prasad, Hyderabad, IN;
Manne Satyanarayana Reddy, Hyderabad, IN;
Muppa Kishore Kumar, Hyderabad, IN;
Srinivasan Thirumalai Rajan, Hyderabad, IN;
Durgadas Shyla Prasad, Hyderabad, IN;
MSN Laboratories Limited, Andhra Pradesh, Hyderabad, IN;
Abstract
A process for the preparation of pure Duloxetine hydrochloride comprises the steps of: a) reacting 1-(thiophen-2-yl)ethanone with dimethylamine hydrochloride, b) purifying the component in a solvent, c) reducing the component with an alkali metal borohydride, d) resolving the compound with a chiral acid, and treating the obtained compound with weak inorganic base, e) reacting the compound to give Duloxetine oxalate salt and f) converting the Duloxetine salt into its hydrochloride salt. Further the purifications of the obtained compound and of two intermediate products are described.