The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2013
Filed:
Aug. 20, 2004
Sateesh K. Natarajan, Bellevue, WA (US);
Ofir Moreno, Seattle, WA (US);
Thomas J. Graddis, Seattle, WA (US);
David F. Duncan, San Diego, CA (US);
Reiner Laus, Bellevue, WA (US);
Feng Chen, Seattle, WA (US);
Sateesh K. Natarajan, Bellevue, WA (US);
Ofir Moreno, Seattle, WA (US);
Thomas J. Graddis, Seattle, WA (US);
David F. Duncan, San Diego, CA (US);
Reiner Laus, Bellevue, WA (US);
Feng Chen, Seattle, WA (US);
Dendreon Corporation, Seattle, WA (US);
Abstract
Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.