The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2013
Filed:
Dec. 24, 2003
Mark Tawa, West Roxbury, MA (US);
Julius Remenar, Framingham, MA (US);
Matthew L. Peterson, Hopkinton, MA (US);
Örn Almarsson, Shrewsbury, MA (US);
Hector Guzman, Jamaica Plain, MA (US);
Hongming Chen, Acton, MA (US);
Mark Oliveira, Framingham, MA (US);
Mark Tawa, West Roxbury, MA (US);
Julius Remenar, Framingham, MA (US);
Matthew L. Peterson, Hopkinton, MA (US);
Örn Almarsson, Shrewsbury, MA (US);
Hector Guzman, Jamaica Plain, MA (US);
Hongming Chen, Acton, MA (US);
Mark Oliveira, Framingham, MA (US);
McNeil-PPC, Inc., Skillman, NJ (US);
Abstract
The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.