The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2013
Filed:
Jun. 16, 2011
Chu-biao Xue, Hockessin, DE (US);
Brian W. Metcalf, Moraga, CA (US);
Hao Feng, Aston, PA (US);
Ganfeng Cao, Newark, DE (US);
Taisheng Huang, Wilmington, DE (US);
Changsheng Zheng, Wilmington, DE (US);
Darius J. Robinson, Wilmington, DE (US);
Amy Qi Han, Hockessin, DE (US);
Chu-Biao Xue, Hockessin, DE (US);
Brian W. Metcalf, Moraga, CA (US);
Hao Feng, Aston, PA (US);
Ganfeng Cao, Newark, DE (US);
Taisheng Huang, Wilmington, DE (US);
Changsheng Zheng, Wilmington, DE (US);
Darius J. Robinson, Wilmington, DE (US);
Amy Qi Han, Hockessin, DE (US);
Incyte Corporation, Wilmington, DE (US);
Abstract
The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R, R, R, R, R, R, R, R, X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.