The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8361981 B1

PDF
Full Text
Expired
Date of Patent:
Jan. 29, 2013

Filed:

Apr. 29, 2009
Applicants:

Martin Gleave, Vancouver, CA;

Paul S. Rennie, Richmond, CA;

Hideaki Miyake, Vancouver, CA;

Colleen Nelson, Surrey, CA;

Tobias Zellweger, Basel, CA;

Inventors:

Martin Gleave, Vancouver, CA;

Paul S. Rennie, Richmond, CA;

Hideaki Miyake, Vancouver, CA;

Colleen Nelson, Surrey, CA;

Tobias Zellweger, Basel, CA;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

Administration of antisense oligodeoxynucleotides (ODN) targeted against the testosterone-repressed prostate message-2 (TRPM-2) gene can reduce the amount of TRPM-2 in renal cell cancer (RCC) cells and other cancer cells, and as a result enhance chemosensitivity of these cells to chemotherapy agents and radiation. Thus, for example, the sensitivity of renal cell cancer cells to a chemotherapeutic agent can be increased by exposing renal cell cancer cells to a chemotherapeutic agent and an agent which reduces the amount of TRPM-2 in the renal cell cancer cells. This provides an improved method for treatment of renal cell cancer, which is generally resistant to treatment with known chemotherapy agents.


Find Patent Forward Citations

Gleave, Martin. (2013). Chemo- and radiation-sensitization of cancer by antisense trpm-2 oligodeoxynucleotides (U.S. Patent No. 8361981). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8361981

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