The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2013
Filed:
Apr. 29, 2009
Martin Gleave, Vancouver, CA;
Paul S. Rennie, Richmond, CA;
Hideaki Miyake, Vancouver, CA;
Colleen Nelson, Surrey, CA;
Tobias Zellweger, Basel, CA;
Martin Gleave, Vancouver, CA;
Paul S. Rennie, Richmond, CA;
Hideaki Miyake, Vancouver, CA;
Colleen Nelson, Surrey, CA;
Tobias Zellweger, Basel, CA;
The University of British Columbia, Vancouver, CA;
Abstract
Administration of antisense oligodeoxynucleotides (ODN) targeted against the testosterone-repressed prostate message-2 (TRPM-2) gene can reduce the amount of TRPM-2 in renal cell cancer (RCC) cells and other cancer cells, and as a result enhance chemosensitivity of these cells to chemotherapy agents and radiation. Thus, for example, the sensitivity of renal cell cancer cells to a chemotherapeutic agent can be increased by exposing renal cell cancer cells to a chemotherapeutic agent and an agent which reduces the amount of TRPM-2 in the renal cell cancer cells. This provides an improved method for treatment of renal cell cancer, which is generally resistant to treatment with known chemotherapy agents.