The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2013
Filed:
Mar. 18, 2007
Applicants:
Annemieke Aartsma-rus, Hoofddorp, NL;
Judith Christina T. Van Deutekom, Dordrecht, NL;
Garrit-jan Boudewijn Van Ommen, Amsterdam, NL;
Inventors:
Annemieke Aartsma-Rus, Hoofddorp, NL;
Judith Christina T. Van Deutekom, Dordrecht, NL;
Garrit-Jan Boudewijn Van Ommen, Amsterdam, NL;
Assignee:
Academisch Ziekenhuis Leiden, Leiden, NL;
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C07H 21/02 (2006.01);
U.S. Cl.
CPC ...
Abstract
In the present invention means and method are provided for optimising exon-skipping using exon-internal AON. We show that skipping efficiencies are improved by targeting putative splicing regulatory sequences (ESEs) within an exon. Such double targeting may be particularly useful for exons with which efficient skipping was difficult to obtain prior to the invention.