The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2013
Filed:
May. 02, 2007
Gang L. Liu, Berkeley, CA (US);
Jonathan A. Ellman, Oakland, CA (US);
Luke P. Lee, Orinda, CA (US);
Fanqing Frank Chen, Moraga, CA (US);
Gang L. Liu, Berkeley, CA (US);
Jonathan A. Ellman, Oakland, CA (US);
Luke P. Lee, Orinda, CA (US);
Fanqing Frank Chen, Moraga, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
This invention pertains to the in vitro detection of proteases using a single peptide-conjugate nanocrescent surface enhanced Raman scattering (SERS) probes with at least nanomolar sensitivity. The probe enables detection of proteolytic activity in extremely small volume and at low concentration. In certain embodiments the probes comprise an indicator for the detection of an active protease, where the indicator comprises a nanocrescent attached to a peptide, where said peptide comprises a recognition site for the protease and a Raman tag attached to the peptide.