The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2013
Filed:
Jun. 14, 2012
Michael Politino, Syracuse, NY (US);
Matthew M. Cadin, Auburn, NY (US);
Paul M. Skonezny, Baldwinsville, NY (US);
Jason G. Chen, Manlius, NY (US);
Michael Politino, Syracuse, NY (US);
Matthew M. Cadin, Auburn, NY (US);
Paul M. Skonezny, Baldwinsville, NY (US);
Jason G. Chen, Manlius, NY (US);
Bristol Myers-Squibb Company, Princeton, NJ (US);
Abstract
A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.