The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2013
Filed:
Sep. 01, 2006
Applicants:
Siyaram Pandey, Lasalle, CA;
Jamshid Tanha, Ottawa, CA;
Deyzi Gueorguieva, Windsor, CA;
Inventors:
Assignees:
National Research Council of Canada, Ottawa, CA;
University of Windsor, Windsor, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07H 21/04 (2006.01); C07K 16/00 (2006.01); G01N 33/53 (2006.01);
U.S. Cl.
CPC ...
Abstract
Single-domain anti-bodies that bind pro-apoptotic proteins Bax and caspase-3 are identified and isolated. These single-domain antibodies may be used to modulate the active of Bax and caspase-3, thereby modulating the symptoms and steps of oxidative stress and/or cell apoptosis, including Bax dimerization, mitochondrial permeabilization and the release of apoptotic proteins.