The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2013
Filed:
May. 22, 2012
Charlotte Albaek Thrue, Copenhagen K, DK;
Anja Molhart Hog, Vium, DK;
Paul E. G. Kristjansen, Horsholm, DK;
Charlotte Albaek Thrue, Copenhagen K, DK;
Anja Molhart Hog, Vium, DK;
Paul E. G. Kristjansen, Horsholm, DK;
Enzon Pharmaceuticals, Inc., Piscataway, NJ (US);
Santaris Pharama A/S, Horsholm, DK;
Abstract
Oligonucleotides directed against the hypoxia-inducible factor-1α (HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.