The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2013
Filed:
Oct. 25, 2005
David A. Stein, Corvallis, OR (US);
Qing GE, Santa Cruz, CA (US);
Jianzhu Chen, Lexington, MA (US);
Patrick L. Iversen, Corvallis, OR (US);
Hong M. Moulton, Corvallis, OR (US);
David A. Stein, Corvallis, OR (US);
Qing Ge, Santa Cruz, CA (US);
Jianzhu Chen, Lexington, MA (US);
Patrick L. Iversen, Corvallis, OR (US);
Hong M. Moulton, Corvallis, OR (US);
AVI BioPharma, Inc., Corvallis, OR (US);
M.I.T., Cambridge, MA (US);
Abstract
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5' or 3′ terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C; b) the terminal 25 bases of the 3′ terminus of the positive sense cRNA and; and c) the 50 bases surrounding the AUG start codon of an influenza viral mRNA.