The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2013
Filed:
Dec. 15, 2005
Gilles Guichard, Wolfisheim, FR;
Sylvie Victorine Lucienne Fournel, Strasbourg, FR;
Olivier Chaloin, Strasbourg, FR;
Nathalie Trouche, Erstein-Krafft, FR;
Sêbastien Wieckowski, Ambilly, FR;
Johan Hoebeke, Kessel-Lo, BE;
Gilles Guichard, Wolfisheim, FR;
Sylvie Victorine Lucienne Fournel, Strasbourg, FR;
Olivier Chaloin, Strasbourg, FR;
Nathalie Trouche, Erstein-Krafft, FR;
Sêbastien Wieckowski, Ambilly, FR;
Johan Hoebeke, Kessel-Lo, BE;
Centre National de la Recherche Scientifique, Paris, FR;
Abstract
A compound of formula (I) is described, wherein Y represents a macrocycle, the ring of which has 9 to 36 atoms, and is functionalized by three amine or COOH functions; Rrepresents a group of formula H—X—X—X—X—X—(X)—, i represents 0 or 1, Xis in particular lysine, arginine, or ornithine residues, Xis in particular glycine, asparagine, L-proline or D-proline residues, Xand Xare in particular tyrosine, phenylalanine or 3-nitrotyrosine residues, Xand Xare in particular amino acid residues: NH—(CH)—COOH, n ranging from 1 to 10, or NH—(CH—CH—O)—CHCHCOOH, m ranging from 3 to 6, provided that at least one of the amino acid residues X, X, Xand Xis different from the corresponding amino acid in the sequence of the natural CD40Lys-Gly-Tyr-Tyrfragment(SEQ ID NO: 1).