The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2013
Filed:
Dec. 28, 2010
Michael F. Clarke, Palo Alto, CA (US);
Sean J. Morrison, Ann Arbor, MI (US);
Max S. Wicha, Ann Arbor, MI (US);
Muhammad Al-hajj, Eagleville, PA (US);
Michael F. Clarke, Palo Alto, CA (US);
Sean J. Morrison, Ann Arbor, MI (US);
Max S. Wicha, Ann Arbor, MI (US);
Muhammad Al-Hajj, Eagleville, PA (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise to both more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.