The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 2013
Filed:
Nov. 03, 2004
Steven W. Ludmerer, North Wales, PA (US);
Donald J. Graham, Green Lane, PA (US);
Robert L. Lafemina, Schwenksville, PA (US);
Osvaldo A. Flores, North Wales, PA (US);
Maura Pizzuti, Rome, IT;
Cinzia Traboni, Rome, IT;
Steven W. Ludmerer, North Wales, PA (US);
Donald J. Graham, Green Lane, PA (US);
Robert L. LaFemina, Schwenksville, PA (US);
Osvaldo A. Flores, North Wales, PA (US);
Maura Pizzuti, Rome, IT;
Cinzia Traboni, Rome, IT;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A., Rome, IT;
Abstract
The present invention features methods for enhancing the ability of a genotype 2b NS5B sequence to function in a replicon, for producing replicons containing a functional genotype 2b NS5B, and for using replicons to measure the ability of a compound to affect HCV replication that is sustained with the genotype 2b polymerase. Also featured is a genotype 1b NS4B adaptive mutation. The ability to produce replicons containing a functional genotype 2b NS5B is illustrated by the production of chimeric replicons based on HCV genotype 1b where substantially all the NS5B sequence is replaced with a genotype 2b NS5B.