The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 2013
Filed:
Dec. 15, 2004
Applicants:
Cathy Mcmahan, Seattle, WA (US);
Lara Porter Stepan, Seattle, WA (US);
Reiner Laus, Bellevue, WA (US);
Damir Vidovic, Bellevue, WA (US);
Inventors:
Cathy McMahan, Seattle, WA (US);
Lara Porter Stepan, Seattle, WA (US);
Reiner Laus, Bellevue, WA (US);
Damir Vidovic, Bellevue, WA (US);
Assignee:
Dendreon Corporation, Seattle, WA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C07K 17/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
HLA-DR-specific monoclonal antibodies are provided that are capable of inducing apoptosis in HLA-DR-expressing tumor cells. Certain exemplary HLA-DR-specific antibodies exhibit reduced levels of immunosuppressive activity. Antibodies of the present invention will find use in diagnostic methods as well as in compositions and methods for the treatment of cancers associated with HLA-DR expressing tumor cells.