The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2013
Filed:
Aug. 22, 2011
Adnan M. M. Mjalli, Oak Ridge, NC (US);
Bapu Gaddam, High Point, NC (US);
Devi Reddy Gohimukkula, Jamestown, NC (US);
Dharma Rao Polisetti, High Point, NC (US);
Hassan El Abdellaoui, Jamestown, NC (US);
Mohan Rao, Greensboro, NC (US);
Pingzhen Wang, Kernersville, NC (US);
Robert Carl Andrews, Jamestown, NC (US);
Rongyuan Xie, Greensboro, NC (US);
Tan Ren, Colfax, NC (US);
Adnan M. M. Mjalli, Oak Ridge, NC (US);
Bapu Gaddam, High Point, NC (US);
Devi Reddy Gohimukkula, Jamestown, NC (US);
Dharma Rao Polisetti, High Point, NC (US);
Hassan El Abdellaoui, Jamestown, NC (US);
Mohan Rao, Greensboro, NC (US);
Pingzhen Wang, Kernersville, NC (US);
Robert Carl Andrews, Jamestown, NC (US);
Rongyuan Xie, Greensboro, NC (US);
Tan Ren, Colfax, NC (US);
High Point Pharmaceuticals, LLC, High Point, NC (US);
Abstract
The present invention is directed to substituted isoquinoline derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.