The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2013
Filed:
Dec. 21, 2009
Susan E. Brophy, Lindenhurst, IL (US);
Saul A. Datwyler, Evanston, IL (US);
David J. Hawksworth, Lake Villa, IL (US);
Don C. Laird, Mundelein, IL (US);
Sharmila Manoj, Arlington Heights, IL (US);
Dominick L. Pucci, Libertyville, IL (US);
Bryan C. Tieman, Elmhurst, IL (US);
Joan Tyner, Beach Park, IL (US);
Lowell J. Tyner, Legal Representative, Chicago, IL (US);
Zhiguang Yu, Libertyville, IL (US);
Susan E. Brophy, Lindenhurst, IL (US);
Saul A. Datwyler, Evanston, IL (US);
David J. Hawksworth, Lake Villa, IL (US);
Don C. Laird, Mundelein, IL (US);
Sharmila Manoj, Arlington Heights, IL (US);
Dominick L. Pucci, Libertyville, IL (US);
Bryan C. Tieman, Elmhurst, IL (US);
Joan Tyner, Beach Park, IL (US);
Lowell J. Tyner, legal representative, Chicago, IL (US);
Zhiguang Yu, Libertyville, IL (US);
Abbott Laboratories, Abbott Park, IL (US);
Abstract
An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.