The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2013
Filed:
Dec. 01, 2009
Alexey Alexandrovich Lugovskoy, Woburn, MA (US);
Karl Hanf, Billerica, MA (US);
You LI, Newton, MA (US);
Kenneth Simon, Cambridge, MA (US);
Herman Van Vlijmen, Mechelen, BE;
Alexey Alexandrovich Lugovskoy, Woburn, MA (US);
Karl Hanf, Billerica, MA (US);
You Li, Newton, MA (US);
Kenneth Simon, Cambridge, MA (US);
Herman Van Vlijmen, Mechelen, BE;
Biogen Idec MA Inc., Cambridge, MA (US);
Abstract
The present invention is based, at least in part, on the discovery that strategic modifications of non-human donor antibody CDR residue(s) can be used to humanize antibodies. Such modifications modulate the 3D structural fit between donor antibody CDRs and human acceptor antibody framework regions that comprise the variable domains of a CDR-grafted antibody. Whereas prior art methods of humanization have relied on making framework substitutions (in which selected human framework residues are backmutated to the corresponding amino acid residue present in the non-human donor antibody), the instant invention is based, at least in part, on a method of humanizing antibodies in which selected CDR residues, and optionally adjacent FR residues, are changed in order to accommodate differences in FR amino acid sequences between donor and acceptor antibodies.