The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2013
Filed:
Apr. 15, 2011
Applicants:
Karl Dane Wittrup, Chestnut Hill, MA (US);
Balaji M. Rao, Cambridge, MA (US);
Douglas A. Lauffenburger, Cambridge, MA (US);
Inventors:
Karl Dane Wittrup, Chestnut Hill, MA (US);
Balaji M. Rao, Cambridge, MA (US);
Douglas A. Lauffenburger, Cambridge, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/20 (2006.01); C07K 14/55 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα.