The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2013
Filed:
Mar. 28, 2011
Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
Aleksandr Yurkovetskiy, Littleton, MA (US);
Mao Yin, Needham, MA (US);
Timothy B. Lowinger, Carlisle, MA (US);
Carolina B. Cabral, Somerset, NJ (US);
Charles E. Hammond, Billerica, MA (US);
Cheri A. Stevenson, Haverhill, MA (US);
Aleksandr Yurkovetskiy, Littleton, MA (US);
Mao Yin, Needham, MA (US);
Timothy B. Lowinger, Carlisle, MA (US);
Carolina B. Cabral, Somerset, NJ (US);
Charles E. Hammond, Billerica, MA (US);
Cheri A. Stevenson, Haverhill, MA (US);
Mersana Therapeutics, Inc., Cambridge, MA (US);
Abstract
A polynucleotide delivery vehicle comprising a modified polymer is provided herein, the modified polymer having the following formula: in which W, W, W, W, W, W, Z, Z, Z, Z, Z, Z, R, R, R, R, R, n, n, n, n, n, and nare defined herein. Also disclosed are methods of delivering a polynucleotide to the cytoplasm of a selected tissue type or cell type and methods of reducing expression of a gene in a cell or a subject in need thereof with the modified polymer.