The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2013
Filed:
Jul. 25, 2008
Igf-1r specific antibodies useful in the detection and diagnosis of cellular proliferative disorders
Liliane Goetsch, Ayze, FR;
David Brooks, Concord, MA (US);
Michael Chastain, Seattle, WA (US);
Zhi-qiang Zhang, Lansdale, PA (US);
Nathalie Corvaia, Collonges sous Saleve, FR;
Liliane Goetsch, Ayze, FR;
David Brooks, Concord, MA (US);
Michael Chastain, Seattle, WA (US);
Zhi-Qiang Zhang, Lansdale, PA (US);
Nathalie Corvaia, Collonges sous Saleve, FR;
Merck Sharp & Dohme Limited, Rahway, NJ (US);
Abstract
The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGF-1R.
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