The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2013
Filed:
Jun. 21, 2006
Thomas Glanmor Davies, Cambridge, GB;
Robert George Boyle, Cambridge, GB;
Ian Collins, Redhill, GB;
Michelle Dawn Garrett, Walton-on-Thames, GB;
Thomas Glanmor Davies, Cambridge, GB;
Robert George Boyle, Cambridge, GB;
Ian Collins, Redhill, GB;
Michelle Dawn Garrett, Walton-on-Thames, GB;
Astex Therapeutics Limited, Cambridge, GB;
The Institute of Cancer Research: Royal Cancer Hospital, London, GB;
Cancer Research Technology Limited, London, GB;
Abstract
The invention provides compounds of the formula (I) having ROCK kinase and/or protein kinase p70S6K inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between R1 and NRRand a maximum chain length of 4 atoms extending between E and NRR, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom α with respect to the NRRgroup and provided that the oxo group when present is located at a carbon atom α with respect to the NRRgroup; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; Ris an aryl or heteroaryl group; and R, R, Rand Rare as defined in the claims.