The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2013
Filed:
Jun. 24, 2010
IN Gyu Kim, Daejeon, KR;
Tae Lim Kim, Daejoen, KR;
Kug Chan Kim, Daejeon, KR;
Eun Jin Kim, Daejeon, KR;
SO Yong Lee, Cheongju-si, KR;
IL Lae Jung, Daejeon, KR;
In Gyu Kim, Daejeon, KR;
Tae Lim Kim, Daejoen, KR;
Kug Chan Kim, Daejeon, KR;
Eun Jin Kim, Daejeon, KR;
So Yong Lee, Cheongju-si, KR;
Il Lae Jung, Daejeon, KR;
Abstract
Disclosed herein is a method for enhancing sensitivity of cancer cells to compounds or radiation by inhibiting the expression of testis-specific protein, Y-encoded like 5 (TSPYL5). More specifically, because methylation of TSPYL5 protein expressed in lung cancer cell line was inhibited to increase the expression level of the gene, resistance to stress such as radiation or anticancer agents was increased. Because the sensitivity of cancer cells to stress such as radiation or anticancer agents was increased by inhibiting the expression of the TSPYL5 gene to promote the apoptosis of the cells, an anticancer supplement agent containing an inhibitor of the expression or activity of the TSPYL5 gene of the present invention inhibits the growth of cancer cells and enhances the sensitivity to various stresses to maximize the apoptosis. Thus, when used in combination with radiotherapy or chemotherapy, the anticancer supplement agent may be used very usefully for anticancer treatment.