The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2013
Filed:
May. 19, 2004
Dianqing Wu, Chesire, CT (US);
Xiaofeng LI, West Hartford, CT (US);
Peng Liu, West Hartford, CT (US);
Wenzhong Liu, Farmington, CT (US);
Dean Engelhardt, New York, NY (US);
Dianqing Wu, Chesire, CT (US);
Xiaofeng Li, West Hartford, CT (US);
Peng Liu, West Hartford, CT (US);
Wenzhong Liu, Farmington, CT (US);
Dean Engelhardt, New York, NY (US);
Enzo Biochem, Inc., Farmingdale, NY (US);
Abstract
Compositions and methods for the treatment of bone diseases, bone fractures, bone injuries and other bone abnormalities involving the use of Dkk protein, a Wnt antagonist, a Wnt inhibitor, or any other related protein for the stimulation or enhancement of mineralization and for stimulating the renewal of cells. One Dkk protein, Dickkopf-2 (Dkk-2), acts to stimulate bone formation independently of Wnt proteins which may be inhibited and/or antagonized by Dkk-2. Dkk-2 displayed enhanced specific targeting ability and enhanced biological activity in stimulating or enhancing mineralization. Dkk-2 also played a role in the differentiation and self-renewal of hematopoietic stem cells and mesenchymal stem cells, particularly in osteoblastogenesis and osteoclastogenesis.