The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2013
Filed:
Mar. 01, 2011
Applicants:
Qiang Deng, Shanghai, CN;
Marie-louise Michel, Paris, FR;
Inventors:
Qiang Deng, Shanghai, CN;
Marie-Louise Michel, Paris, FR;
Assignees:
Institut Pasteur, Paris, FR;
Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, FR;
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 15/09 (2006.01);
U.S. Cl.
CPC ...
Abstract
This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then to viral clearance. The vector of the invention, by expression of epitopes derived from common pathogens, by-passes existing tolerance of virus specific T cell responses. The vector will only replicate in virus infected cells.