The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2013
Filed:
Jul. 19, 2007
Michael Katz, Malmö, SE;
Jochen Förster, København, DK;
Helga David, København, DK;
Hans Peter Schmidt, Holte, DK;
Malin Sendelius, Lund, SE;
Sara Peterson Bjørn, Lyngby, DK;
Thomas Thomasen Durhuus, København, DK;
Michael Katz, Malmö, SE;
Jochen Förster, København, DK;
Helga David, København, DK;
Hans Peter Schmidt, Holte, DK;
Malin Sendelius, Lund, SE;
Sara Peterson Bjørn, Lyngby, DK;
Thomas Thomasen Durhuus, København, DK;
Fluxome Sciences A/S, Lyngby, DK;
Abstract
A genetically engineered micro-organism having an operative metabolic pathway producing cinnamoyl-CoA and producing pinosylvin therefrom by the action of a stilbene synthase is used for pinosylvin production. Said cinnamic acid may be formed from L-phenylalanine by a L-phenylalanine ammonia lyase (PAL) which is one accepting phenylalanine as a substrate and producing cinammic acid therefrom, preferably such that if the PAL also accepts tyrosine as a substrate and forms coumaric acid therefrom, the ratio Km(phenylalanine)/Km(tyrosine) for said PAL is less than 1:1 and if said micro-organism produces a cinammate-4-hydroxylase enzyme (C4H), the ratio K(PAL)/K(C4H) is at least 2:1.