The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2013
Filed:
Aug. 01, 2007
Fumie Kusaki, Joetsu, JP;
Takafumi Hoshino, Joetsu, JP;
Naosuke Maruyama, Joetsu, JP;
Yuichi Nishiyama, Joetsu, JP;
Ikuo Fukui, Joetsu, JP;
Hiroshi Umezawa, Joetsu, JP;
Fumie Kusaki, Joetsu, JP;
Takafumi Hoshino, Joetsu, JP;
Naosuke Maruyama, Joetsu, JP;
Yuichi Nishiyama, Joetsu, JP;
Ikuo Fukui, Joetsu, JP;
Hiroshi Umezawa, Joetsu, JP;
Shin-Etsu Chemical Co., Ltd., , JP;
Abstract
Provided are a solid dosage form comprising an enteric solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising an enteric solid dispersion comprising a poorly soluble drug, an enteric polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m/g. Moreover, provided is a method for producing a solid dosage form comprising an enteric solid dispersion, the method comprising steps of: spraying an enteric polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m/g and serving as a disintegrant; and granulating the resultant; and drying.