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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8338614 B1

PDFFull Text
Date of Patent:
Dec. 25, 2012

Filed:

Jan. 13, 2006

Tertiary carbinamines having substituted heterocycles which are active as β-secretase inhibitors for the treatment of alzheimer's disease

Applicants:

Georgia B. Mcgaughey, Harleysville, PA (US);

Philippe G. Nantermet, Lansdale, PA (US);

Hemaka A. Rajapakse, Wyncote, PA (US);

Shaun R. Stauffer, Schwenksville, PA (US);

Inventors:

Georgia B. McGaughey, Harleysville, PA (US);

Philippe G. Nantermet, Lansdale, PA (US);

Hemaka A. Rajapakse, Wyncote, PA (US);

Shaun R. Stauffer, Schwenksville, PA (US);

Assignee:

Merck, Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Keith D. MacMillan

Gerard M. Devlin

Primary Examiner:

Kamal Saeed

Assistant Examiner:

Nyeemah A Grazier

Int. Cl.
CPC ...
C07D 271/10 (2006.01); C07D 271/113 (2006.01); C07D 271/107 (2006.01); C07D 487/02 (2006.01); C07D 237/26 (2006.01); C07D 413/06 (2006.01); C07D 401/06 (2006.01); C07D 213/02 (2006.01); C07D 243/14 (2006.01); A61K 31/519 (2006.01); A61K 31/141 (2006.01); A61K 31/495 (2006.01); A61K 31/535 (2006.01); A61K 31/55 (2006.01); A61K 31/44 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention is directed to tertiary carbinamine compounds having substituted heterocycles, which are inhibitors of the beta-secretase enzyme, and are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

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