The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 25, 2012

Filed:

Feb. 28, 2008
Applicants:

Amal Wahhab, Laval, CA;

Eric Therrien, Laval, CA;

Martin Allan, Montreal, CA;

Sukhdev Manku, Pincourt, CA;

Inventors:

Amal Wahhab, Laval, CA;

Eric Therrien, Laval, CA;

Martin Allan, Montreal, CA;

Sukhdev Manku, Pincourt, CA;

Assignee:

MethylGene Inc., Montreal, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4162 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to compounds that are useful as inhibitors of protein arginine methyltransferase that have a formula selected from Formula (I), Formula (II) and Formula (III), as well as racemic mixtures, diastereomers, enantiomers and tautomers thereof and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof as defined herein. The compound are useful as inhibitors of PRMTs and/or CARM-I. The invention further relates to compositions comprising such compounds and methods for their use.


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