The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2012
Filed:
Feb. 20, 2009
Qihong Huang, Philadelphia, PA (US);
Alexander Deiters, Raleigh, NC (US);
Kiranmai Gumireddy, Philadelphia, PA (US);
Qihong Huang, Philadelphia, PA (US);
Alexander Deiters, Raleigh, NC (US);
Kiranmai Gumireddy, Philadelphia, PA (US);
The Wistar Institute, Philadelphia, PA (US);
North Carolina State University, Raleigh, NC (US);
Abstract
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.