The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2012
Filed:
Aug. 25, 2008
Bingxiang Xu, Huancheng Donglu, CN;
Haisong Xie, Huancheng Donglu, CN;
Huan Yu, Huancheng Donglu, CN;
Wei Mao, Huancheng Donglu, CN;
Weidong YE, Huancheng Donglu, CN;
Bingxiang Xu, Huancheng Donglu, CN;
Haisong Xie, Huancheng Donglu, CN;
Huan Yu, Huancheng Donglu, CN;
Wei Mao, Huancheng Donglu, CN;
Weidong Ye, Huancheng Donglu, CN;
Zhejiang Medicine Co., Ltd., Zhejiang Province, CN;
Abstract
The present invention provides a deshydroxy vancomycin compound,a method of its preparation and a pharmaceutical composition comprising a pharmaceutically effective amount of the deshydroxy vancomycin and the use of the said composition in the preparation of drugs for the treatment of susceptible bacteria infections. The method includes the following steps: (1) preparing a concentrated vancomycin solution containing the deshydroxy vancomycin by fermentations ofwith Deposit No. CGMCCNO.1183; (2) separating and purifing the concentrated vancomycin solution to obtain a refined filtrate of vancomycin hydrochloride containing the deshydroxy vancomycin by column chromatography; and (3) further separating and purifing the refined filtrate to obtain the deshydroxy vancomycin by chromatography. Wherein, separation and purification is processed by column chromatography in a gel chromatography column containing a salt-water mobile phase, separation and purification is processed by chromatography in a macroporous adsorption resin chromatography column containing a buffer-methanol mobile phase.