The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2012
Filed:
Dec. 13, 2006
Vikas Prabhakar, Cambridge, MA (US);
Ishan Capila, Ashland, MA (US);
Rahul Raman, Arlington, MA (US);
Carlos Bosques, Cambridge, MA (US);
Kevin Pojasek, Cambridge, MA (US);
Ram Sasisekharan, Bedford, MA (US);
Vikas Prabhakar, Cambridge, MA (US);
Ishan Capila, Ashland, MA (US);
Rahul Raman, Arlington, MA (US);
Carlos Bosques, Cambridge, MA (US);
Kevin Pojasek, Cambridge, MA (US);
Ram Sasisekharan, Bedford, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.