The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2012
Filed:
Dec. 22, 2006
Michael Rod Zalutsky, Chapel Hill, NC (US);
Oscar Rodolfo Pozzi, Durham, NC (US);
Michael Rod Zalutsky, Chapel Hill, NC (US);
Oscar Rodolfo Pozzi, Durham, NC (US);
Duke University, Durham, NC (US);
Abstract
Oxidants (e.g., N-chlorosuccinimide) can be used to stabilize α-particle emitters (e.g.,At) in solution, prior to their subsequent reaction to form α-particle emitter labeled compounds (e.g., a radiolabeled pharmaceutical or a radiolabeled pre-cursor used to prepare it). In particular, the use of an oxidant has been found to maintain the α-particle emitter in a chemical form that facilitates this reaction, which may involve a number of possible mechanisms including electrophilic substitution, nucleophilic substitution, complexation, exchange, or metallic bonding. Compounds labeled with α-particle emitters in this manner have wide-ranging therapeutic applications, particularly in the treatment of cancer.