The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2012
Filed:
Mar. 13, 2006
Teresa Bendele, Doylestown, PA (US);
Thomas Harbart, North Royalton, OH (US);
Dave Howard, North Ridgeville, OH (US);
Michael Kagan, Doylestown, PA (US);
Douglas Keene, North Wales, PA (US);
Dave Lapeus, Medina, OH (US);
Jared Mayes, Ambler, PA (US);
Douglas Paynter, Doylestown, PA (US);
Jerry Prohaska, Huntingdon Valley, PA (US);
Herman Rutner, Hatboro, PA (US);
Teresa Bendele, Doylestown, PA (US);
Thomas Harbart, North Royalton, OH (US);
Dave Howard, North Ridgeville, OH (US);
Michael Kagan, Doylestown, PA (US);
Douglas Keene, North Wales, PA (US);
Dave Lapeus, Medina, OH (US);
Jared Mayes, Ambler, PA (US);
Douglas Paynter, Doylestown, PA (US);
Jerry Prohaska, Huntingdon Valley, PA (US);
Herman Rutner, Hatboro, PA (US);
Veridex, LLC, Raritan, NJ (US);
Abstract
The present invention provides a protocol and apparatus for enriching circulating tumor cells and other rare cells from blood, including debris and other components, from samples with high precision and at high throughput rates. This invention discloses an improved processing system from previously described semi-automated sample processing. The system further reduces operator intervention and hands-on time from prior systems. While this system has general utility in processing diverse materials, the system is configured for sample processing of biological specimens to provide an enriched fraction suitable for detection, enumeration and identification of target cells by appropriate analytical methodologies. The presence and quantities of such target cells in a sample specimen can utilized for screening and detection in disease such as cancer, assessing early stage pre-metastatic cancer, monitoring for disease remission in response to therapy and selection of more effective dose regimens or alternative therapies in case of relapse.