The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2012
Filed:
Aug. 14, 2008
Ulrich Westedt, Schriesheim, DE;
Jörg Rosenberg, Ellerstadt, DE;
Martin Knobloch, Neuhofen, DE;
Norbert Steiger, Lingenfeld, DE;
Harald Hach, Oberotterbach, DE;
Ulrich Westedt, Schriesheim, DE;
Jörg Rosenberg, Ellerstadt, DE;
Martin Knobloch, Neuhofen, DE;
Norbert Steiger, Lingenfeld, DE;
Harald Hach, Oberotterbach, DE;
Abbott GmbH & Co. KG, Wiesbaden, DE;
Abstract
A description is given of a process for the preparation of a pharmaceutical composition of a macrolide antibiotic in essentially noncrystalline form, in which the macrolide antibiotic, a water-swellable polymer and a proton donor are blended in an extruder in the presence of water and forced through a die, the ratio by weight of the sum of macrolide antibiotic, water-swellable polymer and proton donor to water being at least 1:1. The macrolide antibiotic is preferably clarithromycin and the water-swellable polymer is preferably chosen from crosslinked polyvinylpyrrolidone, crosslinked sodium carboxymethylcellulose and crosslinked polyacrylic acid.