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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8334280 B1

PDFFull Text
Expired
Date of Patent:
Dec. 18, 2012

Filed:

May. 05, 2009

Ligands of estrogen receptors α and β, method of their preparation, and pharmaceuticals comprising them

Applicants:

Petr Novak, Havlichkuv Brod, CZ;

David Sedlak, Praha, CZ;

Petr Bartunek, Praha, CZ;

Martin Kotora, Praha, CZ;

Inventors:

Petr Novak, Havlichkuv Brod, CZ;

David Sedlak, Praha, CZ;

Petr Bartunek, Praha, CZ;

Martin Kotora, Praha, CZ;

Assignees:

Ustav Molekularni Genetikv AV CR, V.V.I., , CZ;

Ustav Organicke Chemie A Biochemie AV CR, V.V.I., , CZ;

Univerzita Karlova V Praze, Prirodovedecka Fukulta UK, , CZ;

Attorney:

Reinhart Boerner Van Deuren s.c.

Primary Examiner:

Barbara P Badio

Int. Cl.
CPC ...
A61K 31/567 (2006.01); A61K 31/58 (2006.01); C07J 1/00 (2006.01); C07J 17/00 (2006.01); C07J 43/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention relates to novel ligands of the estrogen receptors α and β of general formula II, which are useful as an active substance of pharmaceuticals, for example pharmaceutical compositions useful for hormone replacement therapy, as well as for the treatment of tumors and inflammatory diseases. The invention also relates to a novel preparation method of these ligands comprising cyclotrimerization of ethynylestradiol with the appropriate diyne in an organic solvent. Further, the invention relates to pharmaceuticals comprising the novel compounds according to the invention.

Find Patent Forward Citations

Novak, Petr. (2012). Ligands of estrogen receptors α and β, method of their preparation, and pharmaceuticals comprising them (U.S. Patent No. 8334280). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8334280

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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