The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2012
Filed:
Nov. 19, 2008
Yong Dai, Mechanicsville, PA (US);
Biqing YE, Bergenfield, NJ (US);
Kui Chen, Raleigh, NC (US);
Pau Bruguera, Barcelona, ES;
Daniel Lawson, Wakeforest, NC (US);
Shamay Tang, Miami, FL (US);
Yong Dai, Mechanicsville, PA (US);
Biqing Ye, Bergenfield, NJ (US);
Kui Chen, Raleigh, NC (US);
Pau Bruguera, Barcelona, ES;
Daniel Lawson, Wakeforest, NC (US);
Shamay Tang, Miami, FL (US);
Instrumentation Laboratory Company, Bedford, MA (US);
Abstract
The invention relates generally to a new functional protein S assay and kit that is based on the ability of endogenous protein S to prolong clotting time. In the assay procedure, a test plasma sample is diluted with protein S deficient plasma, followed by the addition of purified or recombinant tissue factor (pTF or rTF), purified natural or synthetic phospholipid (pPL or sPL) and activated protein C (APC) or protein C activator (PCA). The clotting time is then measured and compared to a standard curve or a normal control.