The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2012
Filed:
May. 12, 2005
Larry Brown, Newton, MA (US);
Vered Bisker-leib, Woburn, MA (US);
Debra Lafreniere, Dighton, MA (US);
John Mcgeehan, Woodbury, NJ (US);
Julia Rashba-step, Newton, MA (US);
Terrence Scott, Winchester, MA (US);
Larry Brown, Newton, MA (US);
Vered Bisker-Leib, Woburn, MA (US);
Debra LaFreniere, Dighton, MA (US);
John McGeehan, Woodbury, NJ (US);
Julia Rashba-Step, Newton, MA (US);
Terrence Scott, Winchester, MA (US);
Baxter International, Inc., Deerfield, IL (US);
Baxter Healthcare S.A., Glattpark (Opfikon), CH;
Abstract
The present invention relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical that are substantially amorphous or non-crystalline and are injectable through fine gauge needles at high concentrations. The invention has special application for higher molecular weight proteins.