The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2012
Filed:
Dec. 31, 2008
Vladimir R. Muzykantov, Warwick, PA (US);
Sergei V. Zaitsev, Elkins Park, PA (US);
Bi-sen Ding, New York, NY (US);
Douglas B. Cines, Wynnewood, PA (US);
Vladimir R. Muzykantov, Warwick, PA (US);
Sergei V. Zaitsev, Elkins Park, PA (US);
Bi-Sen Ding, New York, NY (US);
Douglas B. Cines, Wynnewood, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Fusion proteins comprising a single chain antigen-binding domain (scFv) of a monoclonal antibody, linked to an anti-thrombotic agent, anti-inflammatory agent, or a pro-drug thereof are provided, where the polypeptide binds to a binding site (antigen) expressed on the surface of a red blood cell at a density greater than 5,000 copies per red blood cell. Pharmaceutical compositions comprising these fusion proteins, and methods of delivering an anti-thrombotic agent to the surface of a red blood cell via delivery of these fusion proteins, and methods of treating or preventing thrombosis, tissue ischemia, acute myocardial infarction (AMI), ischemic stroke, cerebrovascular disease, pulmonary embolism, or ischemic peripheral vascular disease via administration of the fusion proteins or compositions comprising same are also provided.