The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2012
Filed:
Oct. 04, 2011
Jacques Banchereau, Dallas, TX (US);
Kiley Prilliman, Dallas, TX (US);
Virginia Pascual, Dallas, TX (US);
Anna Karolina Palucka, Dallas, TX (US);
Jacques Banchereau, Dallas, TX (US);
Kiley Prilliman, Dallas, TX (US);
Virginia Pascual, Dallas, TX (US);
Anna Karolina Palucka, Dallas, TX (US);
Baylor Research Institute, Dallas, TX (US);
Abstract
The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha ('IFNα') protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, I, J1, K, 4a, 4b and WA, but does not neutralize at least one bioactivity of IFNα protein subtype D. Examples of bioactivity for measurement include activation of the MxA promoter or antiviral activity and variants, derivatives and fragments thereof. The invention also includes host cells, hybridomas and plasmacytomas that produce antibodies. Because of their unique selectivity and affinity, the antibodies of the present invention are useful to detect IFNα subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFNα related disorder such as SLE, lupus, type I diabetes, psoriasis, AIDS and Graft versus Host Disease.