The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2012
Filed:
Jul. 05, 2005
Jennifer A. Riggs-sauthier, Raleigh, NC (US);
Nnochiri N. Ekwuribe, Cary, NC (US);
Jennifer A. Riggs-Sauthier, Raleigh, NC (US);
Nnochiri N. Ekwuribe, Cary, NC (US);
Biocon Limited, , IN;
Abstract
A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCHCH)—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCHCH)—OH (n=1-4) under basic conditions led to THP-(OCHCH)—OH (n=5-15). Similarly, Me-(OCHCH)—OH (n=4-11, 13) were prepared from Me-(OCHCH)—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCHCH)—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCHCH)—OH (n=1-11, 13) with X—(CH)—COR (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.