The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2012
Filed:
Mar. 22, 2005
Tae Hyoung Kim, Gwangju, KR;
Tae Hyoung Kim, Gwangju, KR;
Chosun University, Gwangju, KR;
Abstract
The present invention relates a novel cell-killing peptide, particularly to a cell-killing peptide that exploits a specific region at the C-terminus of Noxa protein, a 'BH3-only' member of Bcl-2 family causing apoptosis and fusion proteins containing the same. According to the present invention, the cell-killing peptide (CKP) effectively kills a cancer cell such as HeLa or HCT116 when it is conjugated with PTD or CTD domain. Therefore, the cell-killing peptide of the present invention is still stronger to kill cells, compared with conventional substances such as TRAIL, and will be applied widely for various cell therapies, especially in cancer treatment.