The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2012
Filed:
Dec. 10, 2010
Marc Mckennon, Seattle, WA (US);
Giovanni Da Re, Milan, IT;
Luca Feliciotti, Sesto San Giovanni, IT;
Marco Artico, Parabiago, IT;
Gianluca Pardi, Ripafratta, IT;
Mario Grugni, Novate, IT;
Marc McKennon, Seattle, WA (US);
Giovanni Da Re, Milan, IT;
Luca Feliciotti, Sesto San Giovanni, IT;
Marco Artico, Parabiago, IT;
Gianluca Pardi, Ripafratta, IT;
Mario Grugni, Novate, IT;
Cell Therapeutics, Inc., Seattle, WA (US);
Abstract
The invention relates to an improved process for the preparation of poly-α-glutamic acids which comprises the polymerization of tertiary γ-esters of α-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-α-glutamic acid-γ-ester. The process is particularly advantageous in that it allows one to carefully control the molecular weight of the resulting poly-α-glutamic acid. The invention also relates to poly-α-glutamic acids capped at the amino terminus with carboxylic acids or amino acids and to a process for the preparation thereof.